June 2, 2026 · Ophthalmology · DOI: 10.1016/j.ophtha.2026.05.034

Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study

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The authors aimed to investigate the association between semaglutide use and the risk of neovascular age-related macular degeneration (NVAMD) in adults with type 2 diabetes. Their retrospective study, utilizing data from the OHDSI network, found no significant differences in NVAMD risk between semaglutide users and those using other diabetes medications, suggesting that semaglutide does not increase or decrease the risk of NVAMD.

Cindy X Cai, Brian Toy, Benjamin Martin, Ruochong Fan, Erik Westlund, Diep Tran, Akihiko Nishimura, Haeun Lee, Theodore Leng, Paul Nagy, Nestoras Mathioudakis, Linying Zhang, Michelle Hribar, Aiyin Chen, Karen Armbrust, Kerry Goetz, Sally Baxter, Michael V Boland, Eric N Brown, Edmund Tsui, Andrew J Barkmeier, Sophia Wang, Nitish Mehta, Jacqueline C Stocking, Ghazala O'Keefe, Cecilia S Lee, Philip R O Payne, William J O'Brien, Scott DuVall, Thamir Alshammari, Thomas Falconer, David A Dorr, Izabelle Humes, David McCoy, Mohammed Adibuzzaman, Rumel Mahmood, Hannah Morgan-Cooper, Priya Desai, Shikha Yashwant Kothari, Anthony Sena, Clair Blacketer, Anna Ostropolets, Azza Shoaibi, Gowtham Rao, George Hripcsak, Patrick Ryan, Marc A Suchard

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