June 5, 2026 · Heart rhythm · DOI: 10.1016/j.hrthm.2026.06.001

Impact of Anxiety and Depression in Patients with Atrial Fibrillation: Insights from Two International Prospective Registries

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The authors aimed to investigate the impact of anxiety and depression on clinical outcomes in patients with atrial fibrillation (AF) by comparing characteristics and outcomes between those with and without these psychological conditions. Their findings revealed that patients with symptoms of anxiety and/or depression experienced significantly worse outcomes, including higher risks of all-cause death and major adverse cardiovascular events, particularly in those with moderate-to-severe symptoms. This underscores the importance of incorporating psychological assessments into the management of AF.

Michele Rossi, Tommaso Bucci, Enrico Tartaglia, Amir Askarinejad, Andrea Galeazzo Rigutini, Hung-Fat Tse, Claudio Ferri, Giuseppe Boriani, Tze-Fan Chao, Gregory Y H Lip

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