Substitution Patterns After Discontinuation of CNS-Active Medications in Older Adults in Primary Care
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The authors aimed to investigate the frequency and nature of medication substitutions following the discontinuation of central nervous system (CNS)-active medications in older adults. They found that 9.5% of drug discontinuations were followed by substitutions, with 26.2% of these substitutions being potentially inappropriate according to the 2023 Beers Criteria. This underscores the need for improved guidance for prescribers to ensure safe deprescribing practices.
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