June 11, 2026 · Radiographics : a review publication of the Radiological Society of North America, Inc · DOI: 10.1148/rg.250132

Distinguishing Malignant from Benign Causes of Breast Size Changes: A Case-based Primer for the Radiologist

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The authors aim to address the challenge of distinguishing between malignant and benign causes of breast size changes, emphasizing the importance of accurate diagnosis for effective management. Through clinical scenarios, they provide a structured framework that integrates clinical history, physical examination, and imaging findings to guide radiologists in their diagnostic decision-making. The article underscores the role of radiologists in alleviating patient anxiety and directing appropriate care based on the evaluation of breast size changes.

Aurela I Clark, Hannah Conley, Wendi A Owen, Xiaoqin Wang, Nanditha George, Santo Maimone, Haley P Letter, Fara Y Shikoh, Margaret Szabunio

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