June 11, 2026 · Prenatal diagnosis · DOI: 10.1002/pd.70194

Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta-Heart Axis

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The authors aimed to investigate the relationship between placental vascular pathology and the occurrence of congenital heart disease (CHD) in infants. Their findings indicate that maternal vascular malperfusion (MVM) is significantly more prevalent in infants with CHD compared to unaffected infants, suggesting a potential link between placental dysfunction and the development of CHD. Additionally, the study highlights that fetal vascular malperfusion (FVM) is associated with reduced fetal cerebral oxygenation and increased maternal age.

Natalie Lanners, Sarah U Morton, Katherine Le, Steffy Blanco, Sara Mansoorshahi, Chrystalle Katte Carreon, Christina Ronai, Louise Wilkins-Haug, Vidhya Annavajjhala, Jacqueline G Parchem, Tina O Findley

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