June 11, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2026.2675559

Perimenopausal migraine: a narrative review

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This narrative review explores the relationship between perimenopause and migraine, particularly how fluctuating estrogen levels impact the frequency and severity of migraine attacks in women. The authors highlight the lack of research on the effects of menopause hormone therapy (MHT) on migraines during this transitional phase and suggest that hormone cycle control may be a more effective approach for managing migraines in perimenopausal women. They emphasize the need for tailored hormonal treatments to mitigate migraine symptoms while considering the complexities of hormonal fluctuations during perimenopause.

Salwa Kamourieh, E Anne MacGregor

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