June 8, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2026.2675561

The use of menopause hormone therapy in borderline ovarian tumor survivors: a systematic review and meta-analysis

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This systematic review investigates the relationship between menopausal hormone therapy (MHT) and outcomes in survivors of borderline ovarian tumors (BOTs), a type of ovarian neoplasm. The authors found inconsistent evidence regarding the association between MHT and BOTs, with some studies indicating a potential increased risk associated with combined estrogen-progestin therapy, while post-diagnosis safety data remain limited. They conclude that the current literature does not provide sufficient clarity on the impact of MHT on BOT recurrence or survival, highlighting the need for careful, individualized discussions regarding MHT use in this patient population.

Javier Mejia-Gomez, Melissa Tigert, Michelle Jacobson, Elizabeta Shprits, Alison K Shea, Eleni Philippopoulos, Joanne Kotsopoulos, Adam Bridger, Nichole Sanchez Diaz, Pugaliya Puveendrakumaran, Nada Shaltout, Harsukh Benipal, Carys Sosea, Brenna Leslie, Ariel Garzon, Wendy Wolfman, Tiffany Zigras

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