May 8, 2026 · Journal of lower genital tract disease · DOI: 10.1097/LGT.0000000000000957

Clinical Characteristics and Diagnostic Markers of Genital Varicella-zoster in Women: A 12-year Retrospective Cohort

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The authors aimed to characterize the clinical features and diagnostic challenges of genital varicella-zoster virus (VZV) reactivation in women, given its rarity and frequent misdiagnosis. Their retrospective study of 21 female patients revealed that genital zoster is often misidentified as herpes simplex virus (HSV) or other conditions, highlighting key features such as unilateral distribution, pain, and extragenital extension that could improve diagnostic accuracy. The findings underscore the need for better recognition of genital zoster to reduce misclassification and associated psychosocial impacts.

Meller Nir, Rothman Noam, Gilboa Sarit, Baum Micha

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