May 7, 2026 · British journal of anaesthesia · DOI: 10.1016/j.bja.2026.03.042

The environmental footprint and ecotoxicity of sevoflurane and propofol anaesthesia: a retrospective observational modelling study

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The authors aimed to compare the environmental impact and water contamination potential of three anaesthetic strategies: total intravenous anaesthesia (TIVA) with propofol, target-controlled inhalational anaesthesia (TCIA) with sevoflurane, and manually optimised low-flow sevoflurane anaesthesia. Their findings indicate that TIVA with propofol resulted in significantly less water contamination and avoided the release of trifluoroacetic acid (TFA), while sevoflurane methods contributed to higher TFA emissions and its irreversible accumulation in the environment. These results highlight the importance of selecting anaesthetic practices that minimize ecological harm.

Matthieu Bernat, Alain Kalmar, Philippe Cuvillon, Manon Roche, Anne Remacle, Bruno Pastene, Marc Leone, Lionel Bouvet, Hans Peter H Arp, Laurent Zieleskiewicz

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