TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery
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This study investigates the role of TET1 downregulation in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) as a mechanism underlying the delay in surgical pain recovery associated with short-term sleep disturbances. The authors found that sleep disruption leads to decreased TET1 expression, which in turn reduces μ-opioid receptor (MOR) levels, prolonging pain. Restoring TET1 expression mitigated these effects, suggesting that TET1 plays a critical role in pain modulation during sleep disturbances.
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