Microglial activation disrupts hippocampal CA1 sharp-wave ripples via the CA3-CA1 neural circuit that contributes to postoperative memory consolidation deficits in aged mice
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This study investigates how microglial activation affects sharp-wave ripples (SPW-Rs) in the hippocampal CA1 region and contributes to postoperative memory deficits in aged mice. The authors found that surgery-induced microglial activation leads to reduced SPW-R frequency and duration, impairing memory consolidation, while restoring CA3 pyramidal neuron activity can ameliorate these deficits. Ultimately, the research highlights the role of neuroinflammation in postoperative cognitive impairment among elderly patients.
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