Effects of ovarian ablation or suppression on breast cancer recurrence and survival: patient-level meta-analysis of 15 000 women in 23 randomised trials
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The authors aimed to evaluate the impact of ovarian function suppression (OFS) on breast cancer recurrence and survival in premenopausal women with estrogen receptor-positive or unknown early breast cancer. Their meta-analysis of data from 23 randomized trials involving nearly 15,000 women found that OFS significantly reduced recurrence rates and breast cancer mortality, particularly in those confirmed premenopausal after chemotherapy, highlighting its effectiveness regardless of concurrent treatments like tamoxifen.
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