April 23, 2026 · Clinical radiology · DOI: 10.1016/j.crad.2026.107349

Subtle ground enhancement a new definition for breast magnetic resonance imaging (MRI) after neoadjuvant chemotherapy: is it a marker for microscopic residual disease?

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This study investigates the diagnostic value of a newly defined MRI pattern called 'subtle ground enhancement' (SGE) in breast cancer patients following neoadjuvant chemotherapy (NACT) and its correlation with histopathological outcomes. The authors found that SGE was present in 27 out of 332 patients, with a significant proportion showing residual invasive tumors, suggesting that SGE may enhance MRI accuracy in detecting microscopic residual disease post-NACT.

E Yılmaz, M E Mısır, M E Seker, N Guldogan, E B Turk, H Gorucu, M E Aribal

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