Oral Gonadotropin-Releasing Hormone Antagonists for the Treatment of Endometriosis-Associated Pain: A Systematic Review and Meta-Analysis
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The authors aimed to evaluate the efficacy of oral gonadotropin-releasing hormone (GnRH) antagonists compared to placebo in treating endometriosis-associated pain, specifically dysmenorrhea and non-menstrual pelvic pain. Their systematic review and meta-analysis of five phase 3 trials involving over 2,000 participants found that oral GnRH antagonists significantly reduced pain levels, with similar efficacy across different agents, supporting their use as effective second-line treatments for this condition.
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