Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis
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This post hoc analysis of the SURMOUNT-5 trial aimed to investigate how early rapid weight loss affects the efficacy and safety of tirzepatide compared to semaglutide in obesity management. The study found that a higher proportion of participants treated with tirzepatide were rapid responders, achieving greater weight loss by Week 72, although rapid responders experienced more gastrointestinal adverse events without impacting treatment completion rates. Overall, tirzepatide demonstrated superior outcomes in weight reduction compared to semaglutide among both rapid and non-rapid responders.
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