Sex Differences in Clinical Outcomes and Resource Utilization Among Emergency Department Patients With Unexplained Syncope or Presyncope: A Prospective, Observational, Cohort Study

The study aimed to investigate sex differences in baseline characteristics, physician risk estimation, admission rates, and clinical outcomes among emergency department patients aged 40 and older with unexplained syncope or presyncope. The findings revealed that men had higher rates of baseline cardiac disease, were more frequently admitted, and experienced a greater incidence of serious adverse events within 30 days; however, these differences were attributed to variations in baseline clinical factors rather than inherent sex differences. Ultimately, after adjusting for these factors, no significant disparities in admission rates or clinical outcomes remained between men and women.