May 7, 2026 · The American journal of emergency medicine · DOI: 10.1016/j.ajem.2026.04.038

Extended-Release Buprenorphine Administration by Emergency Medical Services Paramedics: A Case Series

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This case series investigates the feasibility of Emergency Medical Services (EMS) administering extended-release buprenorphine (XR-BUP) to individuals with opioid use disorder (OUD) in a 911-based system. The authors aim to determine whether this approach can effectively initiate and maintain medication for opioid use disorder among high-risk populations who face barriers to traditional treatment access. Results indicate successful administration of XR-BUP without adverse effects, leading to improved patient engagement in addiction care, suggesting that EMS may play a crucial role in enhancing treatment access and adherence.

Paul Comber, Rachel Haroz, Jessica Heil, Gerard Carroll

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