On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis

The authors aimed to determine the optimal sodium correction rate in hyponatraemia and its impact on clinical outcomes, particularly mortality and the incidence of osmotic demyelination syndrome (ODS). Their meta-analysis of 11 studies involving 27,672 cases found that rapid sodium correction (at thresholds of 8, 10, and 12 mmol/L/24 hours) was associated with significantly lower mortality rates, although it also correlated with a higher incidence of ODS. The findings suggest that while a more liberal approach to sodium correction may improve survival, the risk of ODS, albeit rare, remains a concern.