March 12, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.02.031

Chest Compression-Only vs Standard CPR in Adult OHCA: Meta-analysis of Randomized Trials and Observational Cohorts on Cardiac and Neurological Outcomes

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The authors aimed to compare the effectiveness of chest compression-only CPR (CCO) versus standard CPR (sCPR) with ventilation in adult out-of-hospital cardiac arrest (OHCA) cases. Their meta-analysis of 18 studies found that both CCO and sCPR resulted in similar survival rates to hospital discharge and neurological outcomes, suggesting that CCO is an effective and simpler strategy for bystander CPR.

Farhad Hasanvand, Ashkan Bahrami, Reza Eshraghi, Ehsan Amini-Salehi, Bahar Darouei, Reza Amani-Beni, Sadegh Mazaheri-Tehrani, Sina Sadati, Pouya Ebrahimi, Mohammad Reza Movahed

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