Umbilical Artery Doppler Deterioration, Time to Delivery, and Risk of Fetal Death in Early-Onset Severe Fetal Growth Restriction Progressing to Absent or Reversed End-Diastolic Flow

The authors aimed to quantify the rate of progression of umbilical artery (UA) Doppler abnormalities, the time to delivery, and the risk of fetal death in a homogeneous cohort of singleton pregnancies with severe placenta-mediated early-onset fetal growth restriction (FGR). They found that the progression of UA Doppler abnormalities occurred over a mean of 7 days, with fetal death risk increasing significantly with the severity of Doppler abnormalities, highlighting the importance of monitoring and timely intervention in these high-risk pregnancies. The study provides critical data to guide clinical management and surveillance strategies for affected patients.