March 21, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.03.012

The association between first trimester iron deficiency without anemia and the development of iron-deficiency anemia prior to childbirth

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The authors aimed to investigate the relationship between first trimester iron deficiency without anemia (IDWA) and the subsequent development of iron-deficiency anemia (IDA) before childbirth. Their findings indicate that individuals with IDWA are nearly twice as likely to develop IDA compared to those who are iron-replete and non-anemic, highlighting the importance of early identification and treatment of IDWA to prevent adverse maternal outcomes.

Nicole Konecke, Tracy L Jackson, Irving Angeles, Iman I Sigman, Crystal F Ware, Ashley E Benson, Joseph J Shatzel, Nandini Raghuraman, Molly J Stout, Ann M Bruno, Steven Fein, Carolyn Webster, Michael Auerbach, Jamie O Lo, Methodius G Tuuli, Adam K Lewkowitz

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