March 12, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.03.002

Parvovirus B19 Infection in Pregnancy: Perinatal Outcomes Derived from a Systematic Review and Meta-Analysis

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This systematic review and meta-analysis aimed to evaluate the perinatal outcomes of Parvovirus B19 infection during pregnancy, particularly comparing the recent outbreak (2023-2024) with previous waves. The study found high rates of intrauterine demise and other complications associated with fetal infections, but no significant differences in these rates between the recent and earlier outbreaks. The findings underscore the need for improved prenatal management strategies and further research on therapeutic interventions and neuroimaging in affected cases.

Sara Sorrenti, Eileen Deuster, Francesco D'Antonio, Daniele D I Mascio, Asma Khalil

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