Safety of Acetaminophen Use in Pregnancy: Review of Existing Evidence

The authors review the safety of acetaminophen use during pregnancy in light of recent concerns regarding its potential links to adverse neurodevelopmental outcomes, such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). They assess the biological plausibility and epidemiological evidence, noting methodological limitations in existing studies, and conclude that while there are some associations, the evidence does not warrant a change in clinical practice, supporting the continued judicious use of acetaminophen in pregnancy.