March 13, 2026 · American journal of obstetrics & gynecology MFM · DOI: 10.1016/j.ajogmf.2026.101934

HIGH VERSUS STANDARD DOSE FOLIC ACID SUPPLEMENTATION FOR MISCARRIAGE PREVENTION: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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The authors aimed to determine whether high-dose folic acid supplementation (4-5 mg/day) before conception reduces the risk of miscarriage and improves pregnancy rates compared to standard-dose supplementation (0.4 mg/day). Their systematic review and meta-analysis of three randomized controlled trials involving 5,144 women indicated that high-dose folic acid significantly reduced miscarriage risk and increased pregnancy rates, although the certainty of evidence was rated as low to moderate. The findings suggest a potential need to revise current folic acid dosage recommendations for women trying to conceive, pending further large-scale studies.

Daniele Vinti, Alexander Fiore, Gianfranco Fornelli, Marco Reschini, Paola Viganò, Edgardo Somigliana, Noemi Salmeri

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HIGH VERSUS STANDARD DOSE FOLIC ACID SUPPLEMENTATION FOR MISCARRIAGE PREVENTION: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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