February 6, 2026 · American journal of obstetrics & gynecology MFM · DOI: 10.1016/j.ajogmf.2026.101910

SSRI use during pregnancy and maternal depression - a nationwide birth cohort study on risks to the mother and the newborn

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This study investigates the association between selective serotonin reuptake inhibitor (SSRI) use during pregnancy and the risk of pregnancy and neonatal complications, while controlling for maternal depression severity. The findings indicate that SSRI use is linked to an increased risk of gestational diabetes and certain neonatal complications, such as low Apgar scores and breathing problems, but may also reduce the risk of preterm birth. The authors highlight the need for further research to understand the implications of these findings on maternal and neonatal health.

Heli Malm, Alan S Brown, Keely Cheslack-Postava, Mika Gissler, David Gyllenberg, Emmi Heinonen, Susanna Hinkka-Yli-Salomäki, Ian W McKeague, Aleksi Tornio, Subina Upadhyaya, Andre Sourander

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