Transcriptomic Plasticity and Its Spatial Architecture Shape Melanoma Response to Immunotherapy and Its Combination With BRAF/MEKi
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The authors aimed to identify the tumor biology underlying resistance to immune checkpoint blockade (ICB) and its efficacy when combined with BRAF/MEK inhibitors in BRAF-mutant melanoma. They discovered two distinct ICB-resistant tumor states—differentiated and undifferentiated—with differing responses to treatment, highlighting the potential for biomarker-driven strategies to optimize therapeutic approaches for melanoma patients. Their findings suggest that certain patient subgroups may benefit more from combined therapies rather than ICB alone, addressing significant gaps in treatment efficacy.
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