September 22, 2026 · Journal of the American Society of Nephrology : JASN · DOI: 10.1681/ASN.0000001282

Hemodiafiltration: Clinical Practice of Today and a Look into the Future

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This review examines the current state and future potential of hemodiafiltration (HDF) as a kidney replacement therapy, particularly its advantages over conventional hemodialysis in improving clinical outcomes such as mortality and hospitalization rates. The authors aim to highlight the prescription variables that influence HDF performance and advocate for a shift towards individualized treatment strategies that incorporate patient-reported outcomes and advanced monitoring technologies. Ultimately, they suggest that high-volume HDF may become the global standard for dialysis due to its effectiveness and potential cost benefits.

Peter J Blankestijn, Sanne Roos, Claudia Barth, Michiel L Bots, Krister Cromm, Andrew Davenport, Jörgen Hegbrant, Giovanni Strippoli, Robin W M Vernooij, Bernard Canaud

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