September 17, 2026 · Journal of the American Society of Nephrology : JASN · DOI: 10.1681/ASN.0000001252

Glucosuria as a Marker of Adherence to Sodium-Glucose Cotransporter 2 Inhibitors and Clinical Outcomes in Real-World Practice

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The authors investigate whether glucosuria can serve as an objective marker of adherence to sodium-glucose cotransporter 2 (SGLT2) inhibitors and its association with clinical outcomes in real-world settings. Their findings indicate that glucosuria is linked to higher adherence rates and is associated with significantly reduced risks of all-cause mortality, heart failure hospitalization, and end-stage kidney disease among patients using SGLT2 inhibitors.

Zongpu Li, Aditya Surapaneni, David M Charytan, Leora Horwitz, Saul Blecker, Jung-Im Shin, Lorna E Thorpe, Michal Melamed, Morgan E Grams

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