Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC
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The authors investigate the mechanisms and immune features that influence the response to neoadjuvant PD-L1 blockade in oesophageal squamous cell carcinoma (ESCC). By analyzing single-cell and spatial transcriptomes, they identify specific cellular programmes linked to treatment efficacy and highlight the role of lymphocyte activation gene 3 as a potential target to enhance responses in non-responders. Their findings aim to inform personalized immunotherapy strategies for ESCC.
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