Recurrence Patterns of Resected Ampullary Adenocarcinoma and Implications for Multimodal Therapy: A Hidden Genome-Derived Analysis from the Ampullary Cancer Collaborative

The authors aimed to investigate how genomic subtypes of resected ampullary adenocarcinoma influence recurrence patterns and survival outcomes, particularly in relation to adjuvant therapies. They found that while genomic subtype significantly affected recurrence-free survival, it did not correlate with local recurrence rates, which were generally low. In contrast, adjuvant chemotherapy was associated with improved overall survival, highlighting the need for tailored treatment strategies based on genomic classification.