September 16, 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS · DOI: 10.1016/j.bjps.2026.08.042

Missed connections: National trends in the utilization of regenerative peripheral nerve interface surgery for major extremity amputation

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The authors aimed to investigate national trends in the utilization of regenerative peripheral nerve interface (RPNI) surgery during major extremity amputations, given its potential to mitigate complications like phantom-limb pain and symptomatic neuromas. Their analysis of data from 2016-2022 revealed that RPNI surgery is underused, with significant disparities based on income, race, and insurance status, and it is predominantly performed in urban teaching hospitals. Despite being associated with higher costs, RPNI surgery did not affect the length of hospital stay, highlighting systemic inequities in access to this preventive surgical care.

Lee D Yang, Nikhil A Gangoli, Michael B Amrami, Jarrod T Bogue

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