August 10, 2026 · Journal of the American College of Surgeons · DOI: 10.1097/XCS.0000000000002121

Preventing Opioid Misuse Through Safe Opioid Use Agreements in Surgery: A Randomized Clinical Trial

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The authors aimed to evaluate the effectiveness of safe opioid use agreements in reducing the disposal of leftover prescription opioids among postoperative patients. In a randomized clinical trial involving 450 adult surgery patients, they found that only a small percentage disposed of unused opioids, and the use of opioid agreements did not significantly improve disposal rates or safe storage practices. These findings suggest that alternative strategies may be necessary to address the issue of postoperative opioid retention.

Jonah J Stulberg, Van Thi Thanh Truong, Willemijn L Schäfer, Cassandra B Iroz, Elias A Chamely, Julie K Johnson

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