The Diagnosis and Prenatal Management of Non-RHD Alloimmunizations

The authors aim to address the challenges in the diagnosis and prenatal management of non-RhD red blood cell alloimmunizations, which are increasingly significant causes of hemolytic disease of the fetus and newborn (HDFN). They highlight the limitations of existing diagnostic algorithms and management protocols, primarily based on RhD alloimmunization, and emphasize the need for antibody-specific strategies to improve risk assessment and individualized care in affected pregnancies. The review discusses current approaches and advancements in non-invasive diagnostic techniques to enhance prenatal management for these cases.