July 30, 2026 · Prenatal diagnosis · DOI: 10.1002/pd.70228

Mirror Syndrome (Ballantyne Syndrome): Prenatal Diagnosis, Pathophysiology, and the Role of Fetal Therapy-A Narrative Review

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This narrative review investigates the complexities of mirror syndrome, a rare condition linked to fetal hydrops, and aims to clarify its prenatal diagnosis, underlying placental pathophysiology, and the potential for targeted fetal therapy. The authors highlight the challenges in differentiating mirror syndrome from preeclampsia and emphasize the importance of early recognition and multidisciplinary management to improve outcomes for both mother and fetus. Additionally, they discuss the promising role of angiogenic biomarkers in aiding diagnosis and the benefits of in utero therapy for resolving fetal hydrops.

Riccardo Tudisco, Pauline Latapie, Anita Romiti, Alexandra Benachi, Maelig Abgral, Alexandre J Vivanti

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