August 4, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.07.019

Prognostic performance of liver stiffness measurements in primary sclerosing cholangitis: the prospective FICUS cohort

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The authors aimed to validate the prognostic value of liver stiffness measurements (LSM) in predicting outcomes for patients with primary sclerosing cholangitis (PSC) in a large, prospective cohort study. They found that both baseline and dynamic LSM are strongly associated with transplant-free survival, indicating that LSM can serve as an effective risk stratification tool and potential surrogate endpoint in clinical trials for PSC.

Olivier Chazouilleres, Jonathan Bellet, Christoph Schramm, Palak Trivedi, Douglas Thorburn, Martti Farkkila, Annarosa Floreani, Albert Pares, Cynthia Levy, Ulrich Beuers, Henriette Ytting, Ehud Zigmond, Andrew Mason, Pietro Invernizzi, Ansgar Lohse, Gideon Hirschfield, Nora Cazzagon, Laura Llovet, Cyriel Ponsioen, Marco Carbone, Katja Fuessel, Francesco Pezzato, Isha Patel, Jeltje Helder, Sheeba Khan, Karima Ben Belkacem, Farid Gaouar, Aymeric Monegier du Sorbier, Chantal Housset, Sara Lemoinne, Pierre-Antoine Soret, Fabrice Carrat, Christophe Corpechot, International PSC Study Group

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