SOX9-driven SPEM cell lineage plasticity is a potential therapeutic target that mitigates risk of metaplastic progression to gastric cancer
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The authors investigate the role of SOX9 in the plasticity of spasmolytic polypeptide-expressing metaplastic (SPEM) cells during gastric carcinogenesis, aiming to understand how SOX9 influences metaplasia development and progression to gastric cancer. Their findings reveal that loss of SOX9 in chief cells prevents metaplasia and disrupts the progression of carcinogenesis, highlighting SOX9 as a critical regulator of SPEM cell lineage evolution and a potential therapeutic target to mitigate gastric cancer risk.
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