Molecular Subtypes of Cholangiocarcinoma and their Translational Implications

The authors aim to elucidate the molecular subtypes of cholangiocarcinoma and their translational implications, highlighting the significant heterogeneity in their etiologies and histopathological characteristics. They explore the genetic and epigenetic factors contributing to this diversity, the actionable targets for treatment, and the potential impact of environmental and biological factors on tumor behavior. The review emphasizes the need for a better understanding of these molecular distinctions to improve therapeutic strategies and address existing knowledge gaps.