July 22, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.07.006

Serotonergic signaling in gastric physiology and motility disorders

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The authors investigate the role of serotonergic signaling in gastric physiology and its implications for motility disorders, aiming to clarify its therapeutic potential and identify evidence gaps. They highlight the importance of serotonin in regulating gastric function and discuss the evolving landscape of serotonergic therapies, particularly focusing on the efficacy of newer agents like 5-HT4 agonists. The review underscores the need for further research to evaluate the effectiveness of these treatments in managing gastric motility disorders.

Bo Konings, Lukas M Balsiger, Jolien Schol, Emily Ruilova Sosoranga, Emidio Scarpellini, Jef Van den Eynde, Pankaj J Pasricha, Jan Tack

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