August 4, 2026 · Gynecologic oncology · DOI: 10.1016/j.ygyno.2026.07.024

The feasibility of a medically supervised preoperative weight loss program in patients with obesity and atypical hyperplasia, or low-grade endometrial carcinoma

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The authors aimed to evaluate the feasibility and efficacy of a medically supervised preoperative weight loss program for women with obesity and atypical hyperplasia or low-grade endometrial carcinoma. The study found that participants experienced significant short-term weight loss, with a mean reduction of 15 kg prior to surgery, suggesting that such interventions may be beneficial for this patient population. However, the authors call for larger comparative studies to further assess the perioperative benefits and oncologic safety of preoperative weight loss.

Christa Aubrey, Bruno Svajger, Jesse Batara, Sarah Chapelsky, Courtney Tromburg, Logan Richard, Sophia Pin

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