Atrial Fibrillation in Transthyretin Amyloid Cardiomyopathy: Mechanisms, Prognostic Implications, and Management

The authors investigate the prevalence and management of atrial fibrillation (AF) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM), noting that AF occurs in over 70% of these patients and often precedes the diagnosis of cardiomyopathy. They highlight the unique challenges in managing AF due to the disease's effects on atrial structure and function, advocating for early rhythm control and considering catheter ablation as a promising option for select patients. The review emphasizes the importance of optimizing AF management as new therapies improve overall survival in ATTR-CM.