Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification
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The authors investigate the role of heparan sulphate (HS) modification in the progression of hepatocellular carcinoma (HCC) and its impact on anti-tumor immunity. They identify galectin-14, a primate-specific oncofetal protein, as a key regulator that enhances HS synthesis, leading to T cell exhaustion and poor patient prognosis. This study highlights galectin-14's potential as both a diagnostic marker and a therapeutic target in HCC.
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