The Teleologic Basis of Kidney Potassium Handling: A Conceptual Review
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This review explores how human kidney potassium handling evolved to manage high potassium loads from a Paleolithic diet, focusing on the molecular mechanisms involved. The authors identify the WNK-SPAK-OSR1 kinase network as a key regulator and discuss how various kidney functions and adaptations, including the "NCC switch" and gut-kidney interactions, prioritize potassium excretion to prevent hyperkalemia. They conclude that despite modern dietary changes, the kidney's capacity to excrete potassium remains crucial for maintaining cellular function and survival.
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