Early Acute T Cell-Mediated Rejection and Kidney Allograft Outcomes

The authors aimed to investigate the impact of early acute T cell-mediated rejection (TCMR) on long-term kidney allograft outcomes, particularly its treatment responses and their association with graft survival. They found that TCMR is common and often resistant to treatment, with persistent TCMR significantly linked to worse graft survival, challenging the perception of TCMR as clinically benign. Their results highlight the need for improved monitoring and targeted therapies to address persistent inflammation in kidney transplant patients.