Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts
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The authors investigate the role of non-HLA antibodies in the severity and prognosis of antibody-mediated rejection (AMR) in kidney allografts, particularly in cases without donor-specific anti-HLA antibodies. They find that higher levels of non-HLA antibodies correlate with increased microvascular inflammation and worse graft outcomes, suggesting that their detection could enhance AMR classification and risk assessment in transplant patients.
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