Early treatment with rasburicase and risk of kidney replacement therapy and death in adults with tumour lysis syndrome: emulated target trial
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The authors aimed to investigate the impact of early rasburicase treatment on the risk of acute kidney injury requiring kidney replacement therapy or death in adults with tumor lysis syndrome (TLS). Their findings indicate that administering rasburicase within 12 hours of TLS onset is associated with a significantly lower risk of these adverse outcomes compared to delayed treatment or no treatment at all. Specifically, early treatment reduced the risk of acute kidney injury or death by approximately one third.
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