July 29, 2026 · BMJ (Clinical research ed.) · DOI: 10.1136/bmj-2026-100103

Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial

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The authors aimed to evaluate the efficacy and safety of antithrombotic treatments (aspirin, clopidogrel, and rivaroxaban) for migraine prevention in patients with patent foramen ovale (PFO). The study found that all antithrombotic agents were non-inferior to metoprolol in reducing migraine days, with rivaroxaban demonstrating superior efficacy compared to metoprolol without increasing the risk of major bleeding events.

Ziping Li, Chuangshi Wang, Yajie Tang, Jing Dong, Jie Dong, Wenbin Ouyang, Fengwen Zhang, Jiahua Pan, Junyi Wan, Yu Han, Kan Yang, Yongsheng Liu, Qinghai Wang, Bo Li, Islamjan Tursun, Qunshan Shen, Shaohui Li, Hengli Lai, Hong Che, Guotao Wang, Qianli Ma, Yongbin Hang, Kai Huang, Youjin Li, Ping Wang, Feng Gao, Wei Liu, Hao Zhang, Hao Hu, Tao You, Huiliang Liu, Lei Chen, Yingzhang Cheng, Caojin Zhang, Rui Wang, Zhisong Chen, Minglian Gong, Qiang Fu, Chuan He, Peijian Wang, Chunjian Shen, Hongwen Tan, Xiaojun Zhang, Xueqin Zhang, Rui Zhang, Yongjun Wang, Xiangbin Pan

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Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial

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