The Renal "Mechanome": Piezo1 as a Transducer of Shear, Tension, and Stiffness in Health and Kidney Disease
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This review investigates the role of Piezo1, a mechanosensitive ion channel, in translating mechanical forces within the kidney into biological responses, particularly in the context of health and disease. The authors aim to elucidate how Piezo1 integrates signals from fluid shear stress, glomerular tension, and extracellular matrix stiffness, influencing nephron function and contributing to various kidney disorders. They propose that understanding Piezo1's mechanotransduction pathways could inform therapeutic strategies aimed at retuning these processes rather than merely inhibiting them.
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