Peripheral artery disease: advances in medical therapy

The authors aim to address the underdiagnosis and undertreatment of peripheral artery disease (PAD) by reviewing recent advances in medical therapy that target its metabolic, lipid, immuno-inflammatory, and thrombotic drivers. They emphasize the importance of a multifaceted management approach, including lifestyle changes and pharmacologic interventions, particularly highlighting the efficacy of dual antithrombotic therapy and novel agents for lipid and diabetes management in improving cardiovascular and limb outcomes in PAD patients. The paper advocates for a phenotype-driven strategy to enhance risk stratification and tailor treatment for individuals across the PAD spectrum.