July 11, 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · DOI: 10.1016/j.nuclcard.2026.102806

Transient Ischemic Dilation with <sup>18</sup>F-flurpiridaz PET: Establishing Thresholds for a Novel Radiotracer

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The authors aimed to establish normal thresholds for transient ischemic dilation (TID) using the novel radiotracer <sup>18</sup>F-flurpiridaz in patients with suspected coronary artery disease (CAD). Through a secondary analysis of the Flurpiridaz-301 trial, they determined stress-specific TID reference thresholds and found that these values varied by stress modality and were influenced by post-reconstruction filtering. The study underscores the need for tracer- and protocol-specific standards for accurate clinical interpretation of TID in nuclear cardiology.

Sevan Letourneau-Shesaf, Yimin Chen, Mark Lemley, Giselle Ramirez, Paul Kavanagh, Aakash Shanbhag, Joanna X Liang, Christopher Buckley, Robert J H Miller, Daniel S Berman, Piotr Slomka

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