Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Audio Summaries

PROGNOSTIC IMPACT OF MYOCARDIAL FLOW RESERVE ASSESSED BY CZT-SPECT

Jun 9, 2026

The authors aimed to evaluate the prognostic impact of myocardial flow reserve (MFR) assessed by cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) in patients with and without obstructive coronary artery disease (CAD). They found that an MFR <2 was significantly associated with an increased risk of adverse cardiovascular events, including death, and demonstrated improved predictive performance when incorporated into risk assessments. This suggests that routine MFR assessment could enhance risk stratification and management of chronic coronary syndromes.

Radiation dosimetry of ¹⁵O-water based on dynamic large axial field of view PET

Jun 9, 2026

The authors aimed to provide more accurate estimates of radiation dosimetry for ¹⁵O-water using dynamic large axial field of view (LAFOV) PET scanning, as previous estimates were based on limited data. Their findings revealed a sex-averaged effective dose coefficient of 0.62 μSv/MBq, leading to a significantly lower effective dose of approximately 0.25 mSv for typical cardiac scans, compared to earlier estimates. This suggests that LAFOV PET can enhance dosimetry accuracy for this radiotracer.

Right Ventricular Metabolic Adaptation to Afterload and Heterogeneous RV-Pulmonary Arterial Coupling in Pre-Capillary Pulmonary Hypertension: An FDG-PET/CMR Study

Jun 4, 2026

The authors aimed to investigate the relationship between right ventricular (RV) metabolic activity, pulmonary vascular load, and RV-pulmonary arterial (RV-PA) coupling in patients with pre-capillary pulmonary hypertension (PH). They found that increased pulmonary vascular resistance (PVR) is associated with enhanced RV glucose metabolism and impaired RV-PA coupling, suggesting that these metabolic changes may indicate early maladaptive adaptation to increased afterload before significant structural remodeling occurs. The study highlights the utility of integrated FDG-PET and CMR imaging in understanding RV adaptation mechanisms in PH.